Sex Hormone-Binding Globulin Blood Test (SHBG)
Decode the hormone binding that shapes your fertility.
Sex Hormone Binding Globulin (SHBG) is a liver-produced glycoprotein that binds to sex hormones, primarily testosterone and oestradiol, regulating the amount of free, biologically active hormone available to tissues. This test measures the level of SHBG in a simple blood sample, providing essential insight for anyone investigating fertility, hormonal imbalance, or conditions such as polycystic ovary syndrome (PCOS), hypogonadism, or thyroid dysfunction. It is particularly valuable when interpreted alongside total testosterone or oestradiol levels, as it helps calculate free hormone indices and clarifies whether symptoms are driven by altered binding capacity rather than absolute hormone production.
Biomarkers Included
Sex Hormone Binding Globulin
- Sex hormone binding globulin (SHBG)
Why it matters
SHBG levels directly influence how much testosterone and oestradiol remain unbound and active in the body. Abnormal SHBG can explain symptoms of androgen excess or deficiency, menstrual irregularities, subfertility, and metabolic conditions. Measuring SHBG gives clinicians a more accurate picture of hormonal status, guiding targeted treatment and improving outcomes in fertility and endocrine care.
Sex Hormone Binding Globulin
- Sex hormone binding globulin (SHBG)
No special preparation required.
For blood tests, we recommend drinking plenty of water beforehand to ensure smooth sample collection. If you are taking any regular medication, continue to do so unless advised otherwise by your doctor.
Important Clinical Information:
This test is a screening tool to monitor and support your overall health. It does not replace your GP or Consultant.
Always discuss your test results, especially any abnormal results, with your GP, who can interpret them in the context of your medical history and overall health.